S.R.Y. has successfully developed and implemented a production line for an innovative material used to diagnose prostate cancer and its metastases. The material is based on PSMA (Prostate specific membrane antigen) and is labeled with 18F.
Today, the most common material in the world for imaging prostate cancer is 68Ga-PSMA, which led to a revolution in the field of imaging in the diagnosis of prostate cancer, with its entry into regular use in 2012.
The advantages of 68Ga-PSMA are:
Increased early diagnosis ability
Improved uptake in tumors
Low background and ability to diagnose metastases, including in small lymph nodes
However, 68Ga-PSMA has several disadvantages:
Relatively low resolution, resulting from the use of the 68Ga isotope
Significant renal clearance and accumulation in the bladder, which limits diagnostic ability
Short half-life, which limits its distribution to distant targets
Limited throughput (3-4 doses per production batch)
The use of generators forces the manufacturer to depend on a third party
As of 2017, the availability and price of generators has been a real challenge
During 2017, several studies were published in the international scientific literature that dealt with the development of an innovative marker based on PSMA and labeled with 18F, namely 18F-PSMA-1007
18F-PSMA-1007 is a marker with improved clinical and pharmacological properties compared to 68Ga-PSMA, which allows for better logistical operation and is attracting great attention among the international nuclear medicine community
The advantages of 18F-PSMA-1007 are:
Improved resolution, resulting from the use of the 18F isotope
Rapid clearance mediated by the liver (hepatobiliary clearance) and reduced absorption in the bladder
Degree of labeling High
Ideal half-life
High-throughput production capacity (high number of doses)
Independent production without dependence on a third party
Improved tumor uptake and high sensitivity, with an emphasis on disease recurrence at very low PSA levels
In light of the outstanding advantages of this material, S.R.Y. launched a regular production line for 18F-PSMA-1007 in 2017
