The human norepinephrine transporter (hNET) is a transmembrane protein responsible for the uptake of norepinephrine into the synaptic terminals of the central and peripheral nervous systems and into neuroendocrine adrenal chromaffin cells. Notably, neural crest tumors, such as neuroblastoma, paraganglioma and pheochromocytoma, are often characterized by high hNET expression1. Iodine-123 labeled meta-iodobenzyl guanidine ([123I]mIBG) has long been employed for hNET imaging.
Numerous publications indicate that meta-18F-fluorobenzyl guanidine ([18F]mFBG), a fluorine-18-labelled analogue mIBG, stands out as an attractive alternative to [123I]mIBG for PET imaging of NET-expressing tumors2-8.
:CLINICAL ADVANTAGES of [18F]mFBG vs. [123I]mIBG
Higher resolution of PET vs SPECT resulting in improved detection of smaller lesions
Higher clearance2 and a potentially lower radiation dose2,9
No thyroid blockage required
Shorter acquisition time
Single-day protocol
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